Aptamer-conjugated liposome system for targeting MUC1-positive cancer: an in silico screening approach

Health Nanotechnology

Table 1 Aptamer sequences and scoring metrics

Aptamer Name	Aptamer Sequence 5’ to 3’	Ionic conditions of binding buffer	dG score	Docking Score	Confidence Score	Affinity (nM)
5TR1	GGGAGACAAGAATAAACGCTCAAG AAGTGAAAATGACAGAACACAACAT TCGACAGGAGGCTCACAACAGGC	100 mM Na⁺ 5 mM Mg²⁺	-2.00	-296.36	0.9492	47.3
MA3	AACCGCCCAAATCCCTAAGAGTCG GACTGCAACCTATGCTATCGTTGAT GTCTGTCCAAGCAACACAGACACA CTACACACGCACA	140 mM Na⁺ 1 mM Mg²⁺	-8.62	-279.99	0.9308	38.3
S 1.6	GGGAGACAAGAATAAACGCTCAAG CAACAGGGTATCCAAAGGATCAAAT TCGACAGGAGGCTCACAACAGGC	700 mM Na⁺	-2.27	-286.72	0.9390	0.2131
S 2.2	GCAGTTGATCCTTTGGATACCCTGG	140 mM Na⁺	-1.57	-251.94	0.8848	0.135
STRG2	GAGACAAGAATAAACGCTCAAGGCT ATAGCACATGGGTAAAACGACTTCG ACAGGAGGCTCACAACAGGC	150 nM Na⁺ 5 nM Mg²⁺	-2.67	-279.06	0.9296	18.6

This table displays the following information: the names of the aptamers, their ionic conditions of binding buffer, dG scores of 2D modeling, as well as the binding affinity, docking score, and confidence score of the lipo-aptamer and MUC1 interaction

ISSN: 2948-1937